Amoxicillin is a semi synthetic broad-spectrum penicillin drugs, its antibacterial spectrum and antibacterial activity are basically same as the ampicillin; but its acid resistance is stronger than ampicillin; its bactericidal effect is stronger and faster than the latter, but can not be used for the treatment of meningitis. The half-life period is about 61.3 minutes. Amoxicillin is stable under acidic conditions and the gastrointestinal absorption rate is up to 90%, compared with ampicillin absorption, it is more quickly and completely. Except Shigella effect poorer than ampicillin, the effect of the rest is similar.
Amoxicillin has a strong bactericidal effect and the strong ability to penetrate the cell wall.
Lactam groups in pharmaceutical molecules after oral administration immediately hydrolyze to peptide bonds, rapidly bind to transpeptidase in the thalli and inactivate, cut off the only way to used to build cell wall by the thalli rely on the transpeptidase to compound glycopeptides, to cause bacterial cells to rapidly become spherical and rupture dissolution, finally the cell wall was lost, and the water was continuously penetrated, which caused the bursting death. For most of the pathogenic bacteria G+ bacteria and G- bacteria (including cocci and bacilli) have strong antibacterial and bactericidal effect. One of Sreptococcus pneumoniae, Streptococcus mutans, no producing penicillinase staphylococcus, Enterococcus faecalis etc. aerobic gram positive coccus, Escherichia coli, Proteus mirabilis, Salmonella, Haemophilus influenzae, Neisseria gonorrhoeae etc.
hemolytic streptococcus, Streptococcus, penicillinase Staphylococcus, Enterococcus faecalis and other gram positive cocci, Escherichia coli, proteus bacteria, Salmonella, Haemophilus influenzae, Neisseria gonorrhoeae etc. aerobic gram negative bacteria no-producingβLactamase strains and Helicobacter pylori have good antibacterial activity.
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